Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism. The genes encoding clock proteins are expressed throughout the brain, though it is unknown whether these proteins...

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Hlavní autoři: Musiek, Erik S., Lim, Miranda M., Yang, Guangrui, Bauer, Adam Q., Qi, Laura, Lee, Yool, Roh, Jee Hoon, Ortiz-Gonzalez, Xilma, Dearborn, Joshua T., Culver, Joseph P., Herzog, Erik D., Hogenesch, John B., Wozniak, David F., Dikranian, Krikor, Giasson, Benoit I., Weaver, David R., Holtzman, David M., FitzGerald, Garret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859381/
https://ncbi.nlm.nih.gov/pubmed/24270424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70317
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