5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

Somatic mutations in Isocitrate Dehydrogenase 1 (IDH1) are frequent in low grade and progressive gliomas and are characterized by the production of 2-hydroxyglutarate (2-HG) from α-ketoglutarate by the mutant enzyme. 2-HG is an “oncometabolite” that competitively inhibits α-KG dependent dioxygenases...

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Bibliographische Detailangaben
Hauptverfasser: Borodovsky, Alexandra, Salmasi, Vafi, Turcan, Sevin, Fabius, Armida W. M., Baia, Gilson S., Eberhart, Charles G., Weingart, Jon D., Gallia, Gary L., Baylin, Stephen B., Chan, Timothy A., Riggins, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858560/
https://ncbi.nlm.nih.gov/pubmed/24077805
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