Genetic Interaction between Mutations in c-Myb and the KIX Domains of CBP and p300 Affects Multiple Blood Cell Lineages and Influences Both Gene Activation and Repression

Adult blood cell production or definitive hematopoiesis requires the transcription factor c-Myb. The closely related KAT3 histone acetyltransferases CBP (CREBBP) and p300 (EP300) bind c-Myb through their KIX domains and mice homozygous for a p300 KIX domain mutation exhibit multiple blood defects. P...

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Detalhes bibliográficos
Main Authors: Kasper, Lawryn H., Fukuyama, Tomofusa, Lerach, Stephanie, Chang, Yunchao, Xu, Wu, Wu, Song, Boyd, Kelli L., Brindle, Paul K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858336/
https://ncbi.nlm.nih.gov/pubmed/24340053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082684
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