CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation

It remains uncertain how the DNA sequence of mammalian genes influences the transcriptional response to extracellular signals. Here, we show that the number of CREB-binding sites (CREs) affects whether the related histone acetyltransferases (HATs) CREB-binding protein (CBP) and p300 are required for...

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Sonraí Bibleagrafaíochta
Main Authors: Kasper, Lawryn H, Lerach, Stephanie, Wang, Jianmin, Wu, Song, Jeevan, Trushar, Brindle, Paul K
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982758/
https://ncbi.nlm.nih.gov/pubmed/20859256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.235
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