Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms

CREB is a key mediator of cAMP- and calcium-inducible transcription, where phosphorylation of serine 133 in its Kinase-Inducible Domain (KID) is often equated with transactivation. Phospho-Ser133 is required for CREB to bind the KIX domain of the coactivators CBP and p300 (CBP/p300) in vitro, althou...

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Hauptverfasser: Xu, Wu, Kasper, Lawryn H, Lerach, Stephanie, Jeevan, Trushar, Brindle, Paul K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894772/
https://ncbi.nlm.nih.gov/pubmed/17525731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601734
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