CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation

It remains uncertain how the DNA sequence of mammalian genes influences the transcriptional response to extracellular signals. Here, we show that the number of CREB-binding sites (CREs) affects whether the related histone acetyltransferases (HATs) CREB-binding protein (CBP) and p300 are required for...

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Auteurs principaux: Kasper, Lawryn H, Lerach, Stephanie, Wang, Jianmin, Wu, Song, Jeevan, Trushar, Brindle, Paul K
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982758/
https://ncbi.nlm.nih.gov/pubmed/20859256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.235
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