Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

A comprehensive analysis was performed to investigate how inhibition of the human bile salt export pump (BSEP/ABCB11) relates to clinically observed drug-induced liver injury (DILI). Inhibition of taurocholate (TA) transport was investigated in BSEP membrane vesicles for a data set of 250 compounds,...

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Autores principales: Pedersen, Jenny M., Matsson, Pär, Bergström, Christel A. S., Hoogstraate, Janet, Norén, Agneta, LeCluyse, Edward L., Artursson, Per
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858191/
https://ncbi.nlm.nih.gov/pubmed/24014644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft197
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