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Technical Pitfalls and Improvements for High-speed Screening and QSAR Analysis to Predict Inhibitors of the Human Bile Salt Export Pump (ABCB11/BSEP)

Drug-induced hepatotoxicity is one of the major problems encountered in drug discovery and development. Selection of a candidate compound for pre-clinical studies in the drug discovery process is a critical step that can determine the speed and expenditure of clinical development. Because inhibition...

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Autori principali: Saito, Hikaru, Osumi, Masako, Hirano, Hiroyuki, Shin, Wangsoo, Nakamura, Ryota, Ishikawa, Toshihisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758130/
https://ncbi.nlm.nih.gov/pubmed/19688600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-009-9137-9
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