Resistance to Bleomycin in Cancer Cell Lines Is Characterized by Prolonged Doubling Time, Reduced DNA Damage and Evasion of G2/M Arrest and Apoptosis

BACKGROUND: To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance using human cancer cell lines. Seven BLM-resistant cell lines were established by exposure to escalating BLM concentrations over a period of 16-24 months. IC(50) values and cell doubling...

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Detalhes bibliográficos
Main Authors: Wang, Qi, Cui, Kangping, Espin-Garcia, Osvaldo, Cheng, Dangxiao, Qiu, Xiaoping, Chen, Zhuo, Moore, Malcolm, Bristow, Robert G., Xu, Wei, Der, Sandy, Liu, Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857806/
https://ncbi.nlm.nih.gov/pubmed/24349265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082363
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