Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe(2+) and O(2)), BLM causes both single-stranded (ss) and double-stranded (ds) DNA damage with the latter thought to be the major source of cytotoxicity. Previous...

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Sonraí Bibleagrafaíochta
Main Authors: Chen, Jingyang, Ghorai, Manas K., Kenney, Grace, Stubbe, JoAnne
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2008
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441780/
https://ncbi.nlm.nih.gov/pubmed/18492718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn302
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