Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage.
Using various end-labeled, defined-sequence DNA substrates, we examined bleomycin-induced damage at several G.C base pairs which correspond to mutational hot spots. The most frequent lesions detected were single-strand breaks and single apurinic/apyrimidinic (AP) sites at the C residue, suggesting t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1700429/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.21.8350 |
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