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GC-MS methods to quantify the 2-deoxypentos-4-ulose and 3′-phosphoglycolate pathways of 4′-oxidation of 2-deoxyribose in DNA: Application to DNA damage produced by γ-radiation and bleomycin
DNA oxidation plays a substantive role in the pathophysiology of human diseases such as cancer. While the chemistry of nucleobase lesions has dominated studies of DNA damage, there is growing evidence that oxidation of 2-deoxyribose in DNA plays a critical role in the genetic toxicology of oxidative...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2529375/ https://ncbi.nlm.nih.gov/pubmed/17944541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700164y |
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