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GC-MS methods to quantify the 2-deoxypentos-4-ulose and 3′-phosphoglycolate pathways of 4′-oxidation of 2-deoxyribose in DNA: Application to DNA damage produced by γ-radiation and bleomycin

DNA oxidation plays a substantive role in the pathophysiology of human diseases such as cancer. While the chemistry of nucleobase lesions has dominated studies of DNA damage, there is growing evidence that oxidation of 2-deoxyribose in DNA plays a critical role in the genetic toxicology of oxidative...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Chen, Bingzi, Zhou, Xinfeng, Taghizadeh, Koli, Chen, Jingyang, Stubbe, JoAnne, Dedon, Peter C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2007
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529375/
https://ncbi.nlm.nih.gov/pubmed/17944541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700164y
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