HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

Histone deacetylases (HDACs) and acetyltransferases have important roles in the regulation of protein acetylation, chromatin dynamics and the DNA damage response. Here, we show in human colon cancer cells that dietary isothiocyanates (ITCs) inhibit HDAC activity and increase HDAC protein turnover wi...

Full description

Saved in:
Bibliographic Details
Main Authors: Rajendran, Praveen, Kidane, Ariam I., Yu, Tian-Wei, Dashwood, Wan-Mohaiza, Bisson, William H., Löhr, Christiane V., Ho, Emily, Williams, David E., Dashwood, Roderick H.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857341/
https://ncbi.nlm.nih.gov/pubmed/23770684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.24710
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items