HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

Histone deacetylases (HDACs) and acetyltransferases have important roles in the regulation of protein acetylation, chromatin dynamics and the DNA damage response. Here, we show in human colon cancer cells that dietary isothiocyanates (ITCs) inhibit HDAC activity and increase HDAC protein turnover wi...

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Detaylı Bibliyografya
Asıl Yazarlar: Rajendran, Praveen, Kidane, Ariam I., Yu, Tian-Wei, Dashwood, Wan-Mohaiza, Bisson, William H., Löhr, Christiane V., Ho, Emily, Williams, David E., Dashwood, Roderick H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2013
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857341/
https://ncbi.nlm.nih.gov/pubmed/23770684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.24710
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