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HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

Histone deacetylases (HDACs) and acetyltransferases have important roles in the regulation of protein acetylation, chromatin dynamics and the DNA damage response. Here, we show in human colon cancer cells that dietary isothiocyanates (ITCs) inhibit HDAC activity and increase HDAC protein turnover wi...

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書誌詳細
主要な著者: Rajendran, Praveen, Kidane, Ariam I., Yu, Tian-Wei, Dashwood, Wan-Mohaiza, Bisson, William H., Löhr, Christiane V., Ho, Emily, Williams, David E., Dashwood, Roderick H.
フォーマット: Artigo
言語:Inglês
出版事項: Landes Bioscience 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857341/
https://ncbi.nlm.nih.gov/pubmed/23770684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.24710
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