Inhibition of DNA Glycosylases via Small Molecule Purine Analogs

Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potential targets in combination chemotherapeutic strategies...

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Detalhes bibliográficos
Main Authors: Jacobs, Aaron C., Calkins, Marcus J., Jadhav, Ajit, Dorjsuren, Dorjbal, Maloney, David, Simeonov, Anton, Jaruga, Pawel, Dizdaroglu, Miral, McCullough, Amanda K., Lloyd, R. Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857224/
https://ncbi.nlm.nih.gov/pubmed/24349107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081667
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