Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression

Elevated blood pressure (BP) and chronic kidney disease (CKD) are complex traits representing major global health problems(1,2). Multiple genome-wide association studies (GWAS) identified common variants giving independent susceptibility for CKD and hypertension in the promoter of the UMOD gene(3-9)...

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Main Authors: Trudu, Matteo, Janas, Sylvie, Lanzani, Chiara, Debaix, Huguette, Schaeffer, Céline, Ikehata, Masami, Citterio, Lorena, Demaretz, Sylvie, Trevisani, Francesco, Ristagno, Giuseppe, Glaudemans, Bob, Laghmani, Kamel, Dell’Antonio, Giacomo, Loffing, Johannes, Rastaldi, Maria P., Manunta, Paolo, Devuyst, Olivier, Rampoldi, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856354/
https://ncbi.nlm.nih.gov/pubmed/24185693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3384
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