Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis

Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is the most abundant protein in normal urine. Defective uromodulin processing is associated with various kidney disorders. The luminal release and subsequent polymerization...

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發表在:Sci Rep
Main Authors: Olinger, Eric, Lake, Jennifer, Sheehan, Susan, Schiano, Guglielmo, Takata, Tomoaki, Tokonami, Natsuko, Debaix, Huguette, Consolato, Francesco, Rampoldi, Luca, Korstanje, Ron, Devuyst, Olivier
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707305/
https://ncbi.nlm.nih.gov/pubmed/31444371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48300-3
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