The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK

Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the gene encoding ROMK, are associated with urinary levels o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schiano, Guglielmo, Glaudemans, Bob, Olinger, Eric, Goelz, Nadine, Müller, Michael, Loffing-Cueni, Dominique, Deschenes, Georges, Loffing, Johannes, Devuyst, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925250/
https://ncbi.nlm.nih.gov/pubmed/31863061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55771-x
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