The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly exerts its function as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage lead...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Brunati, Martina, Perucca, Simone, Han, Ling, Cattaneo, Angela, Consolato, Francesco, Andolfo, Annapaola, Schaeffer, Céline, Olinger, Eric, Peng, Jianhao, Santambrogio, Sara, Perrier, Romain, Li, Shuo, Bokhove, Marcel, Bachi, Angela, Hummler, Edith, Devuyst, Olivier, Wu, Qingyu, Jovine, Luca, Rampoldi, Luca
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2015
Ämnen:
Biochemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755741/
https://ncbi.nlm.nih.gov/pubmed/26673890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08887
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