The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly exerts its function as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage lead...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Brunati, Martina, Perucca, Simone, Han, Ling, Cattaneo, Angela, Consolato, Francesco, Andolfo, Annapaola, Schaeffer, Céline, Olinger, Eric, Peng, Jianhao, Santambrogio, Sara, Perrier, Romain, Li, Shuo, Bokhove, Marcel, Bachi, Angela, Hummler, Edith, Devuyst, Olivier, Wu, Qingyu, Jovine, Luca, Rampoldi, Luca
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2015
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755741/
https://ncbi.nlm.nih.gov/pubmed/26673890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08887
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