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The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution
Common variants in the UMOD gene encoding uromodulin, associated with risk of hypertension and CKD in the general population, increase UMOD expression and urinary excretion of uromodulin, causing salt-sensitive hypertension and renal lesions. To determine the effect of selective pressure on variant...
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| Publicado no: | J Am Soc Nephrol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5042664/ https://ncbi.nlm.nih.gov/pubmed/26966016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070830 |
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