The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution

Common variants in the UMOD gene encoding uromodulin, associated with risk of hypertension and CKD in the general population, increase UMOD expression and urinary excretion of uromodulin, causing salt-sensitive hypertension and renal lesions. To determine the effect of selective pressure on variant...

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Dades bibliogràfiques
Publicat a:J Am Soc Nephrol
Autors principals: Ghirotto, Silvia, Tassi, Francesca, Barbujani, Guido, Pattini, Linda, Hayward, Caroline, Vollenweider, Peter, Bochud, Murielle, Rampoldi, Luca, Devuyst, Olivier
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2016
Matèries:
Brief Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042664/
https://ncbi.nlm.nih.gov/pubmed/26966016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070830
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