Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an inherited disorder that causes progressive kidney damage and renal failure. Mutations in the UMOD gene, encoding uromodulin, lead to ADTKD-UMOD related. Uromodulin is a GPI-anchored protein exclusively produced by epithelial cells of...

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Publicado no:Sci Rep
Main Authors: Trudu, Matteo, Schaeffer, Celine, Riba, Michela, Ikehata, Masami, Brambilla, Paola, Messa, Piergiorgio, Martinelli-Boneschi, Filippo, Rastaldi, Maria Pia, Rampoldi, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547146/
https://ncbi.nlm.nih.gov/pubmed/28785050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07804-6
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