Active-Site Inhibitors Modulate the Dynamic Properties of Human Monoacylglycerol Lipase: A Hydrogen Exchange Mass Spectrometry Study

Human monoacylglycerol lipase (hMGL) regulates endocannabinoid signaling primarily by deactivating the lipid messenger 2-arachidonoylglycerol. Agents that carbamylate hMGLs catalytic Ser(122) constitute a leading class of therapeutically promising hMGL inhibitors. We have applied peptide-level hydro...

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Hlavní autoři: Karageorgos, Ioannis, Wales, Thomas E., Janero, David R., Zvonok, Nikolai, Vemuri, V. Kiran, Engen, John R., Makriyannis, Alexandros
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855488/
https://ncbi.nlm.nih.gov/pubmed/23795559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400430k
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