Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

Tau immunotherapy is effective in transgenic mice, but the mechanisms of Tau clearance are not well known. To this end, Tau antibody uptake was analyzed in brain slice cultures and primary neurons. Internalization was rapid (<1 h), saturable, and substantial compared with control mouse IgG. Furth...

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Hlavní autoři: Congdon, Erin E., Gu, Jiaping, Sait, Hameetha B. R., Sigurdsson, Einar M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853292/
https://ncbi.nlm.nih.gov/pubmed/24163366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.491001
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