Accelerated clearance and degradation of cell free HIV by neutralizing antibodies occurs via FcγRIIb on liver sinusoidal endothelial cells by endocytosis

Neutralizing antibodies suppress HIV infection by accelerating viral clearance from blood circulation, in addition to neutralization. The elimination mechanism is largely unknown. We determined that human liver sinusoidal endothelial cells (LSEC) express FcγRIIb as the lone Fc gamma receptor, and, u...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Turman, James M., Cheplowitz, Alana M., Tiwari, Charu, Thomas, Thushara, Joshi, Dhruvi, Bhat, Menakshi, Wu, Qian, Pong, Erik, Chu, Seung Y., Szymkowski, David E., Sharma, Amit, Seveau, Stephanie, Robinson, John M., Kwiek, Jesse J., Burton, Dennis, Rajaram, Murugesan VS., Kim, Jonghan, Hangartner, Lars, Ganesan, Latha P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946731/
https://ncbi.nlm.nih.gov/pubmed/33568400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000772
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