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Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease
Impairment of synaptic plasticity underlies memory dysfunction in Alzheimer’s disease (AD). Molecules involved in this plasticity such as PSD-95, a major scaffold protein at excitatory synapses, may play an important role in AD pathogenesis. We examined the distribution of PSD-95 in transgenic mice...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437675/ https://ncbi.nlm.nih.gov/pubmed/21630115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0843-x |
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