Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

Impairment of synaptic plasticity underlies memory dysfunction in Alzheimer’s disease (AD). Molecules involved in this plasticity such as PSD-95, a major scaffold protein at excitatory synapses, may play an important role in AD pathogenesis. We examined the distribution of PSD-95 in transgenic mice...

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Bibliographic Details
Main Authors: Shao, Charles Y., Mirra, Suzanne S., Sait, Hameetha B. R., Sacktor, Todd C., Sigurdsson, Einar M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437675/
https://ncbi.nlm.nih.gov/pubmed/21630115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0843-x
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