Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration

BACKGROUND: Posttranslational modifications of beta amyloid (Aβ) have been shown to affect its biophysical and neurophysiological properties. One of these modifications is N-terminal pyroglutamate (pE) formation. Enzymatic glutaminyl cyclase (QC) activity catalyzes cyclization of truncated Aβ(3-x),...

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Main Authors: Becker, Andreas, Kohlmann, Stephanie, Alexandru, Anca, Jagla, Wolfgang, Canneva, Fabio, Bäuscher, Christoph, Cynis, Holger, Sedlmeier, Reinhard, Graubner, Sigrid, Schilling, Stephan, Demuth, Hans-Ulrich, von Hörsten, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850634/
https://ncbi.nlm.nih.gov/pubmed/24083638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-14-108
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