Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population. Accumulation, aggregation, and deposition of amyloid-β (Aβ) peptides generated through proteolytic cleavage of amyloid precursor protein (APP) are likely initiating events in the pathogenesis of AD. While...

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Main Authors: Kanekiyo, Takahisa, Cirrito, John R., Liu, Chia-Chen, Shinohara, Mitsuru, Li, Jie, Schuler, Dorothy R., Shinohara, Motoko, Holtzman, David M., Bu, Guojun
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2013
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850043/
https://ncbi.nlm.nih.gov/pubmed/24305823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3487-13.2013
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