Therapeutic Administration of Plasminogen Activator Inhibitor-1 Prevents Hypoxic–Ischemic Brain Injury in Newborns

Disruption of the integrity of the blood–brain barrier (BBB) is an important mechanism of cerebrovascular diseases, including neonatal cerebral hypoxia–ischemia (HI). Although both tissue-type plasminogen activator (tPA) and matrix metalloproteinase-9 (MMP-9) can produce BBB damage, their relationsh...

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Autors principals: Yang, Dianer, Nemkul, Niza, Shereen, Ahmed, Jone, Alice, Dunn, R. Scott, Lawrence, Daniel A., Lindquist, Diana, Kuan, Chia-Yi
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
Matèries:
Brief Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849700/
https://ncbi.nlm.nih.gov/pubmed/19587273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1117-09.2009
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