Taming Neonatal Hypoxic-Ischemic Brain Injury by Intranasal Delivery of Plasminogen Activator Inhibitor-1

BACKGROUND AND PURPOSE: Plasminogen Activator Inhibitor-I (PAI-1), a ~50 kDa serine protease inhibitor, markedly reduces the extravascular toxicity of tissue-type plasminogen activator (tPA) in experimental hypoxic-ischemic (HI) brain injury of newborns. However, the current treatment with PAI-1 req...

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Main Authors: Yang, Dianer, Sun, Yu-Yo, Lin, Xiaoyi, Baumann, Jessica M., Warnock, Mark, Lawrence, Daniel A., Kuan, Chia-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021397/
https://ncbi.nlm.nih.gov/pubmed/23881953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.113.001233
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