L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

Metabolites are emerging as key mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. We found that the nonessential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells into mesenchymal-li...

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Hlavní autoři: Comes, Stefania, Gagliardi, Miriam, Laprano, Nicola, Fico, Annalisa, Cimmino, Amelia, Palamidessi, Andrea, De Cesare, Dario, De Falco, Sandro, Angelini, Claudia, Scita, Giorgio, Patriarca, Eduardo J., Matarazzo, Maria R., Minchiotti, Gabriella
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849245/
https://ncbi.nlm.nih.gov/pubmed/24319666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.09.001
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