L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

Metabolites are emerging as key mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. We found that the nonessential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells into mesenchymal-li...

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מידע ביבליוגרפי
Main Authors: Comes, Stefania, Gagliardi, Miriam, Laprano, Nicola, Fico, Annalisa, Cimmino, Amelia, Palamidessi, Andrea, De Cesare, Dario, De Falco, Sandro, Angelini, Claudia, Scita, Giorgio, Patriarca, Eduardo J., Matarazzo, Maria R., Minchiotti, Gabriella
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2013
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849245/
https://ncbi.nlm.nih.gov/pubmed/24319666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.09.001
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