Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation

The conserved human LIN28 RNA-binding proteins function in development, maintenance of pluripotency and oncogenesis. We used PAR-CLIP and a newly developed variant of this method, iDo-PAR-CLIP, to identify LIN28B targets as well as sites bound by the individual RNA-binding domains of LIN28B in the h...

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Bibliographic Details
Main Authors: Graf, Robin, Munschauer, Mathias, Mastrobuoni, Guido, Mayr, Florian, Heinemann, Udo, Kempa, Stefan, Rajewsky, Nikolaus, Landthaler, Markus
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849162/
https://ncbi.nlm.nih.gov/pubmed/23770886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.25194
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