An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates

Lin28 is an evolutionarily conserved RNA-binding protein that inhibits processing of pre-let-7 microRNAs (miRNAs) and regulates translation of mRNAs that control developmental timing, pluripotency, metabolism, and tumorigenesis. The RNA features that mediate Lin28 binding to the terminal loops of le...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: O'Day, Elizabeth, Le, Minh T. N., Imai, Shunsuke, Tan, Shen Mynn, Kirchner, Rory, Arthanari, Haribabu, Hofmann, Oliver, Wagner, Gerhard, Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505039/
https://ncbi.nlm.nih.gov/pubmed/26045559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665521
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