On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

Quadruplexes DNA are present in telomeric DNA as well as in several cancer-related gene promoters and hence affect gene expression and subsequent biological processes. The conformations of G4 provide selective recognition sites for small molecules and thus these structures have become important drug...

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Bibliografische gegevens
Hoofdauteurs: Iachettini, Sara, Stevens, Malcolm FG, Frigerio, Mark, Hummersone, Marc G, Hutchinson, Ian, Garner, Thomas P, Searle, Mark S, Wilson, David W, Munde, Manoj, Nanjunda, Rupesh, D’Angelo, Carmen, Zizza, Pasquale, Rizzo, Angela, Cingolani, Chiara, De Cicco, Federica, Porru, Manuela, D’Incalci, Maurizio, Leonetti, Carlo, Biroccio, Annamaria, Salvati, Erica
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2013
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849007/
https://ncbi.nlm.nih.gov/pubmed/24330541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-68
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