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Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
The pentacyclic acridinium salt RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino [4,3,2-kl] acridinium methosulfate, compound 1) is one of the most interesting DNA G-quadruplex binding molecules due to its high efficacy in tumor cell growth inhibition both in in vitro models and in vivo against human...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4193996/ https://ncbi.nlm.nih.gov/pubmed/25288403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-014-0081-x |
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