Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

The pentacyclic acridinium salt RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino [4,3,2-kl] acridinium methosulfate, compound 1) is one of the most interesting DNA G-quadruplex binding molecules due to its high efficacy in tumor cell growth inhibition both in in vitro models and in vivo against human...

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Detalhes bibliográficos
Main Authors: Rizzo, Angela, Iachettini, Sara, Zizza, Pasquale, Cingolani, Chiara, Porru, Manuela, Artuso, Simona, Stevens, Malcolm, Hummersone, Marc, Biroccio, Annamaria, Salvati, Erica, Leonetti, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193996/
https://ncbi.nlm.nih.gov/pubmed/25288403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-014-0081-x
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