Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases

BACKGROUND AND PURPOSE: Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and increased oxidative stress in vitro. In this phase II study, we eval...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Rojas-Puentes, Luis L, Gonzalez-Pinedo, Marcelino, Crismatt, Alejando, Ortega-Gomez, Alette, Gamboa-Vignolle, Carlos, Nuñez-Gomez, Rodrigo, Dorantes-Gallareta, Yusmiren, Arce-Salinas, Claudia, Arrieta, Oscar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2013
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848663/
https://ncbi.nlm.nih.gov/pubmed/24010771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-8-209
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