Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases

BACKGROUND AND PURPOSE: Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and increased oxidative stress in vitro. In this phase II study, we eval...

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Autors principals: Rojas-Puentes, Luis L, Gonzalez-Pinedo, Marcelino, Crismatt, Alejando, Ortega-Gomez, Alette, Gamboa-Vignolle, Carlos, Nuñez-Gomez, Rodrigo, Dorantes-Gallareta, Yusmiren, Arce-Salinas, Claudia, Arrieta, Oscar
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848663/
https://ncbi.nlm.nih.gov/pubmed/24010771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-8-209
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