Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases

BACKGROUND AND PURPOSE: Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and increased oxidative stress in vitro. In this phase II study, we eval...

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Detaylı Bibliyografya
Asıl Yazarlar: Rojas-Puentes, Luis L, Gonzalez-Pinedo, Marcelino, Crismatt, Alejando, Ortega-Gomez, Alette, Gamboa-Vignolle, Carlos, Nuñez-Gomez, Rodrigo, Dorantes-Gallareta, Yusmiren, Arce-Salinas, Claudia, Arrieta, Oscar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848663/
https://ncbi.nlm.nih.gov/pubmed/24010771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-8-209
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