Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial

PURPOSE: Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function. PATIENTS AND METHODS: A total of 198 adult brain tumor survivors ≥ 6 months after partia...

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Опубликовано в: :J Clin Oncol
Главные авторы: Rapp, Stephen R., Case, L. Doug, Peiffer, Ann, Naughton, Michelle M., Chan, Michael D., Stieber, Volker W., Moore, Dennis F., Falchuk, Steven C., Piephoff, James V., Edenfield, William J., Giguere, Jeffrey K., Loghin, Monica E., Shaw, Edward G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Clinical Oncology 2015
Предметы:
Original Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429174/
https://ncbi.nlm.nih.gov/pubmed/25897156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.58.4508
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