Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial

PURPOSE: Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function. PATIENTS AND METHODS: A total of 198 adult brain tumor survivors ≥ 6 months after partia...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Rapp, Stephen R., Case, L. Doug, Peiffer, Ann, Naughton, Michelle M., Chan, Michael D., Stieber, Volker W., Moore, Dennis F., Falchuk, Steven C., Piephoff, James V., Edenfield, William J., Giguere, Jeffrey K., Loghin, Monica E., Shaw, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429174/
https://ncbi.nlm.nih.gov/pubmed/25897156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.58.4508
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