Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

[Image: see text] The design, synthesis, and evaluation of the potency of new isoform-selective inhibitors of sphingosine kinases 1 and 2 (SK1 and SK2), the enzyme that catalyzes the phosphorylation of d-erythro-sphingosine to produce the key signaling lipid, sphingosine 1-phosphate, are described....

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Main Authors: Baek, Dong Jae, MacRitchie, Neil, Anthony, Nahoum G., Mackay, Simon P., Pyne, Susan, Pyne, Nigel J., Bittman, Robert
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848335/
https://ncbi.nlm.nih.gov/pubmed/24164513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401399c
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