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Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors
[Image: see text] The design, synthesis, and evaluation of the potency of new isoform-selective inhibitors of sphingosine kinases 1 and 2 (SK1 and SK2), the enzyme that catalyzes the phosphorylation of d-erythro-sphingosine to produce the key signaling lipid, sphingosine 1-phosphate, are described....
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| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3848335/ https://ncbi.nlm.nih.gov/pubmed/24164513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401399c |
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