Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines

BACKGROUND: Increased motility and invasiveness of cancer cells are reminiscent of the epithelial-mesenchymal transition (EMT), which occurs during cancer progression and metastasis. Recent studies have indicated the expression of receptor activator of nuclear factor-κB (RANK) in various solid tumor...

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Main Authors: Tsubaki, Masanobu, Komai, Makiko, Fujimoto, Shin-ichiro, Itoh, Tatsuki, Imano, Motohiro, Sakamoto, Kotaro, Shimaoka, Hirotaka, Takeda, Tomoya, Ogawa, Naoki, Mashimo, Kenji, Fujiwara, Daiichiro, Mukai, Junji, Sakaguchi, Katsuhiko, Satou, Takao, Nishida, Shozo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847095/
https://ncbi.nlm.nih.gov/pubmed/24011086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-62
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