Bisphosphonates and statins inhibit expression and secretion of MIP-1α via suppression of Ras/MEK/ERK/AML-1A and Ras/PI3K/Akt/AML-1A pathways

Osteolytic bone disease in multiple myeloma (MM) is associated with upregulated osteoclast activity. Macrophage inflammatory protein-1α (MIP-1α) is crucially involved in the development of osteolytic bone lesions in MM. We previously reported that minodronate inhibited lipopolysaccharide-induced MIP...

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Bibliografiska uppgifter
I publikationen:Am J Cancer Res
Huvudupphovsmän: Tsubaki, Masanobu, Takeda, Tomoya, Sakamoto, Kotaro, Shimaoka, Hirotaka, Fujita, Arisa, Itoh, Tatsuki, Imano, Motohiro, Mashimo, Kenji, Fujiwara, Daiichiro, Sakaguchi, Katsuhiko, Satou, Takao, Nishida, Shozo
Materialtyp: Artigo
Språk:Inglês
Publicerad: e-Century Publishing Corporation 2014
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300689/
https://ncbi.nlm.nih.gov/pubmed/25628928
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