Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation

BACKGROUND: Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit osteoclasts and prevented prenylated small GTPase. However, whether bisphosphona...

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Detalhes bibliográficos
Main Authors: Tsubaki, Masanobu, Komai, Makiko, Itoh, Tatsuki, Imano, Motohiro, Sakamoto, Kotaro, Shimaoka, Hirotaka, Takeda, Tomoya, Ogawa, Naoki, Mashimo, Kenji, Fujiwara, Daiichiro, Mukai, Junji, Sakaguchi, Katsuhiko, Satou, Takao, Nishida, Shozo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996180/
https://ncbi.nlm.nih.gov/pubmed/24490900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-21-10
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