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Islet amyloid polypeptide toxicity and membrane interactions

Islet amyloid polypeptide (IAPP) is responsible for amyloid formation in type 2 diabetes and contributes to the failure of islet cell transplants, however the mechanisms of IAPP-induced cytotoxicity are not known. Interactions with model anionic membranes are known to catalyze IAPP amyloid formation...

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Détails bibliographiques
Auteurs principaux: Cao, Ping, Abedini, Andisheh, Wang, Hui, Tu, Ling-Hsien, Zhang, Xiaoxue, Schmidt, Ann Marie, Raleigh, Daniel P.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845181/
https://ncbi.nlm.nih.gov/pubmed/24218607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305517110
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